Description
Research overview
AOD-9604 Research Background
AOD-9604 is a synthetic 16-amino-acid peptide that corresponds to the C-terminal fragment (residues 176–191) of the human growth hormone molecule, with a tyrosine added at the N-terminus to stabilize the sequence. Because it reproduces only this terminal region rather than the full hormone, it is studied in the research literature as a metabolic peptide fragment distinct from intact growth hormone. Cataloged under CAS 221231-10-3 with the molecular formula C78H123N23O23S2 and an average mass near 1815 Da, this 5 mg presentation is supplied as a lyophilized reference material for in-vitro and preclinical laboratory research use only.
Investigational interest in AOD-9604 stems from how a short C-terminal hGH fragment behaves in adipose and metabolic model systems while lacking the full-length hormone’s growth-signaling domains. The compound has no established consumer application, and the surrounding body of work remains preliminary and ongoing. Data generated in cell-based and animal-model systems characterize the material’s laboratory behavior and should not be extrapolated to human or animal outcomes.
What Has Been Studied in Preclinical Models
Reported experimental work with AOD-9604 has centered on lipid-metabolism model systems. Datasets in the published preclinical record have examined the fragment’s association with adipose-tissue lipolytic activity and reported changes in beta-3 adrenergic receptor expression in fat-cell models. A recurring observation described across these studies is that measured signals on fat-metabolism endpoints were reported without corresponding changes to insulin sensitivity, glucose tolerance, or circulating IGF-1 in the model systems examined, a profile the literature contrasts with that of intact growth hormone. These are descriptions of experimental observations in laboratory systems, not statements of effect in humans or animals.
- Adipocyte and adipose-tissue models probing lipolytic-pathway activity.
- Studies of beta-3 adrenergic receptor expression in fat-cell systems.
- Metabolic-marker panels assessing glucose, insulin, and IGF-1 responses in laboratory settings.
- Cartilage and joint-repair models, including preparations combining the peptide with hyaluronic acid, examined in osteoarthritis-relevant preclinical systems.
Separate lines of investigation have used AOD-9604 in cartilage-model and joint-repair systems, where it has been studied alone and in combination with hyaluronic acid as a matrix component. These descriptions summarize laboratory research observations only and do not establish safety, efficacy, or any outcome for any use.
The studies referenced here describe experimental research findings in laboratory systems, not consumer outcomes. They are not medical claims, do not establish safety or efficacy for any use, and must not be interpreted as guidance for administration to humans or animals. This material is for in-vitro laboratory research only, and nothing on this page constitutes medical advice.
AOD-9604 specifications
| Compound | AOD-9604 |
|---|---|
| Also known as | hGH fragment 177-191 analog (Tyr-hGH 177-191) |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Molecular weight | 1815.1 g/mol |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide-bridged) |
| Form | Lyophilized (freeze-dried) powder |
| Vial contents | 5 mg |
| Purity & identity | Documented on the lot-specific Certificate of Analysis (HPLC purity, mass spectrometry identity) |
| Storage | −20 °C, sealed, dry, protected from light |
| Intended use | Laboratory and analytical research use only. Not for human or veterinary use. |
Storage and handling of lyophilized AOD-9604
Store lyophilized material at −20 °C or below, sealed, dry, and protected from light. Short-term storage at 2–8 °C is generally acceptable. Allow the sealed vial to reach room temperature before opening to limit moisture condensation, and minimize repeated temperature cycling.
Frequently asked questions
What is the CAS number of AOD-9604?
The CAS Registry Number for AOD-9604 is 221231-10-3.
What is the molecular weight of AOD-9604?
AOD-9604 has a molecular formula of C78H123N23O23S2 and an average molecular weight of 1815.1 g/mol.
How should lyophilized AOD-9604 be stored?
Store lyophilized material at −20 °C or below, sealed, dry, and protected from light. Short-term storage at 2–8 °C is generally acceptable. Allow the sealed vial to reach room temperature before opening to limit moisture condensation, and minimize repeated temperature cycling.
Is a Certificate of Analysis available for AOD-9604?
Yes. Each lot is documented with a lot-specific Certificate of Analysis covering identity and purity. Published certificates are listed in our COA Library, searchable by product or lot number.
Is AOD-9604 intended for human or veterinary use?
No. AOD-9604 is sold strictly for laboratory, analytical, and scientific research. It is not intended for human or veterinary use, diagnosis, or treatment. See our Research Disclaimer.
