Description
Research overview
Ipamorelin Research Background
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) supplied here as a 5 mg lyophilized reference material for in-vitro and preclinical laboratory work. It carries the molecular formula C38H49N9O5 and CAS number 170851-70-4. Structurally it is a short, sequence-defined amidated peptide built partly from non-natural residues — the alpha-aminoisobutyric acid (Aib) cap and the D-configured 2-naphthylalanine and phenylalanine — which distinguish it from a simple linear chain of proteinogenic amino acids. In the research literature Ipamorelin is classified as a growth-hormone secretagogue and is frequently described as one of the more receptor-selective members of that peptide family, which is why it recurs as a comparator compound in mechanistic studies.
Interest in Ipamorelin as a research substance centers on its reported selectivity at the growth-hormone secretagogue receptor (GHSR-1a, the ghrelin receptor) in cell-based systems. It is used on the bench as a tool compound for probing this receptor and associated signaling readouts. The compound has no established consumer application; the surrounding body of work is preliminary and ongoing, and results from receptor assays and rodent-model experiments should not be extrapolated to human or animal outcomes.
What Has Been Studied in Preclinical Models
Published investigations involving Ipamorelin are predominantly in-vitro and rodent-model in nature. Reported experimental lines of inquiry include GHSR-1a receptor-binding and functional-activation assays, comparisons of secretagogue selectivity against related peptides, and measurement of downstream signaling endpoints in cultured pituitary-derived cells. Researchers have also used the peptide in isolated-tissue and rodent-model preparations to characterize dose-response behavior and receptor pharmacology under controlled laboratory conditions.
- Receptor-level assays characterizing binding and functional activation at the ghrelin/GHSR-1a receptor in transfected or pituitary-derived cell lines.
- Comparative selectivity studies against other growth-hormone secretagogue peptides in vitro.
- Rodent-model and isolated-tissue preparations examining secretagogue pharmacology and dose-response relationships.
- Stability and identity assays used to characterize the pentapeptide’s behavior in solution.
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment.
Ipamorelin specifications
| Compound | Ipamorelin |
|---|---|
| CAS number | 170851-70-4 |
| Molecular formula | C38H49N9O5 |
| Molecular weight | 711.9 g/mol |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Form | Lyophilized (freeze-dried) powder |
| Vial contents | 5 mg |
| Purity & identity | Documented on the lot-specific Certificate of Analysis (HPLC purity, mass spectrometry identity) |
| Storage | −20 °C, sealed, dry, protected from light |
| Intended use | Laboratory and analytical research use only. Not for human or veterinary use. |
Storage and handling of lyophilized Ipamorelin
Store lyophilized material at −20 °C or below, sealed, dry, and protected from light. Short-term storage at 2–8 °C is generally acceptable. Allow the sealed vial to reach room temperature before opening to limit moisture condensation, and minimize repeated temperature cycling.
Frequently asked questions
What is the CAS number of Ipamorelin?
The CAS Registry Number for Ipamorelin is 170851-70-4.
What is the molecular weight of Ipamorelin?
Ipamorelin has a molecular formula of C38H49N9O5 and an average molecular weight of 711.9 g/mol.
How should lyophilized Ipamorelin be stored?
Store lyophilized material at −20 °C or below, sealed, dry, and protected from light. Short-term storage at 2–8 °C is generally acceptable. Allow the sealed vial to reach room temperature before opening to limit moisture condensation, and minimize repeated temperature cycling.
Is a Certificate of Analysis available for Ipamorelin?
Yes. Each lot is documented with a lot-specific Certificate of Analysis covering identity and purity. Published certificates are listed in our COA Library, searchable by product or lot number.
Is Ipamorelin intended for human or veterinary use?
No. Ipamorelin is sold strictly for laboratory, analytical, and scientific research. It is not intended for human or veterinary use, diagnosis, or treatment. See our Research Disclaimer.
